Designing interactive systems is an interdisciplinary field in which computer scientists, engineers, neuro-scientists, radiologists, psychologists, social scientists, design professionals and others play important roles. The goal of this field is to solve real problems in the design and use of technology, making computer controlled and computer-based systems easier to useeffective for people and organizations. Ease of use fitting the technical level of operator and effectiveness in services are critical to the success of any systems that interact with people, including software systems, home, office and factory appliances, web applications, infotainment systems, medical diagnostics and treatment systems, learning systems etc. ACM IIITA is going to organize Second International Conference on Intelligent Interactive Technologies and Multimedia (IITM 2011) conference to bring together researchers working on all aspects of aforesaid and related devices and solutions seamlessly on human-centered design of interactive systems and multimedia technologies. All original contributions will be welcome which address a wide range of theoretical and practical application issues in development of First International Conference on Intelligent Interactive Technologies and Multimedia (IITM 2011).